Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression
نویسندگان
چکیده
منابع مشابه
X-Linked Lymphoproliferative Disease
2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity. It binds a protein termed Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which in turn has been proposed to function as a regulator of the 2B4-associated signal transduction pathway. In this study, we analyzed pat...
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Systemic vasculitis is an uncommon manifestation of X-linked lymphoproliferative disease (XLP), a disorder in which there is a selective immune deficiency to Epstein-Barr virus (EBV). The molecular basis for XLP has recently been ascribed to mutations within SLAM-associated protein (SAP), an SH2 domain-containing protein expressed primarily in T cells. The authors describe a patient who died as...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2000
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(200006)30:6<1691::aid-immu1691>3.0.co;2-k